Tenofovir Disoproxil Fumarate (TDF)
Tenofovir disoproxil fumarate (TDF) belongs to a class of antiviral medications called nucleotide reverse transcriptase inhibitors (NRTIs). It blocks the activity of reverse transcriptase in HIV, and HBV polymerase in Hepatitis B, preventing the viruses from multiplying.
Dosage by Body Weight
The standard adult dose is 300 mg taken orally once daily, with or without food. For pediatric patients, dosing is based on weight. Renal function (creatinine clearance) must be assessed prior to starting therapy and monitored regularly.
- Body Weight
- Below 5 kg
- Dose
- Not recommended
- Frequency
- N/A
- Tracking Notes
- Safety and efficacy have not been established in this weight range.
- Body Weight
- 5-7 kg
- Dose
- Not recommended
- Frequency
- N/A
- Tracking Notes
- TDF is generally not recommended for children weighing less than 10 kg.
- Body Weight
- 8-10 kg
- Dose
- 80 mg to 100 mg (using oral powder)
- Frequency
- Once daily
- Tracking Notes
- Dosed at approximately 8 mg/kg. Only use if alternative pediatric regimens are unavailable, under strict medical supervision.
- Body Weight
- 11-15 kg
- Dose
- 100 mg to 150 mg
- Frequency
- Once daily
- Tracking Notes
- Can use 150 mg low-strength pediatric tablets or equivalent oral powder.
- Body Weight
- 16-20 kg
- Dose
- 150 mg
- Frequency
- Once daily
- Tracking Notes
- Standard pediatric tablet strength of 150 mg is commonly used for this weight range.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not recommended | N/A | Safety and efficacy have not been established in this weight range. |
| 5-7 kg | Not recommended | N/A | TDF is generally not recommended for children weighing less than 10 kg. |
| 8-10 kg | 80 mg to 100 mg (using oral powder) | Once daily | Dosed at approximately 8 mg/kg. Only use if alternative pediatric regimens are unavailable, under strict medical supervision. |
| 11-15 kg | 100 mg to 150 mg | Once daily | Can use 150 mg low-strength pediatric tablets or equivalent oral powder. |
| 16-20 kg | 150 mg | Once daily | Standard pediatric tablet strength of 150 mg is commonly used for this weight range. |
Formulation
Purpose
Used in combination with other antiretroviral agents for the treatment of HIV-1 infection, and as monotherapy for the treatment of chronic hepatitis B virus (HBV) infection.
Generic Name
Tenofovir Disoproxil FumarateBranded Drug Names
Tenofovir Disoproxil Fumarate (TDF) is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.